Phenotypic Expressions of CCR5-Δ32/Δ32 Homozygosity
نویسندگان
چکیده
منابع مشابه
The Microenvironment in Gliomas: Phenotypic Expressions.
The microenvironment of malignant gliomas is described according to its definition in the literature. Beside tumor cells, a series of stromal cells (microglia/macrophages, pericytes, fibroblasts, endothelial cells, normal and reactive astrocytes) represents the cell component, whereas a complex network of molecular signaling represents the functional component. Its most evident expressions are ...
متن کاملPhenotypic expressions of childhood wheezing and asthma: implications for therapy.
A sthma is a highly variable disease, in terms of presentation, disease progression over time, and response to therapy. As such, the diagnosis and treatment of asthma in young children and adolescents is often challenging. The differential diagnosis has been described elsewhere and is beyond the scope of this article. At any age, recurrent lower respiratory symptoms associated with cough, wheez...
متن کاملThe frequency of CCR5 promoter polymorphisms and CCR5 32 mutation in Iranian populations
Evidence showed that chemokines serve as pro-migratory factors for immune cells. CCL3, CCL4 and CCL5, as the main CC chemokines subfamily members, activate immune cells through binding to CC chemokine receptor 5 or CCR5. Macrophages, NK cells and T lymphocytes express CCR5 and thus, affected CCR5 expression or functions could be associated with altered immune responses. Deletion of 32 base pai...
متن کاملCcr5
Adipose tissue macrophage (ATM) accumulation through C-C motif chemokine receptor 2 (CCR2) and its ligand monocyte chemoattractant protein-1 (MCP-1) is considered pivotal in the development of insulin resistance. However, our new study has demonstrated that CCR5, a different CC chemokine receptor, plays an important role in the ATM recruitment and activation and subsequent development of insuli...
متن کاملAlteration of RH gene structure and expression in human dCCee and DCW-red blood cells: phenotypic homozygosity versus genotypic heterozygosity.
This report describes a comparative study on the dCCee and DCW-red blood cells devoid of RhD and CcEe antigens, respectively. Southern blots showed that the two variants carried opposite deletions in the D and non-D (CcEe) genes. Rh haplotyping and exon polymerase chain reaction (PCR) assay indicated that the deletions did not extend beyond the 5' region upstream from exon 1 or the 3' region do...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Acquired Immune Deficiency Syndromes
سال: 1999
ISSN: 1077-9450
DOI: 10.1097/00042560-199909010-00010